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What kind of performance are you looking to get out of Trail Boss powder?
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I loaded a few 250 gr XTP's with 14.5 gr Trail boss. Nice load. You get a little push straight back with very little muzzel flip. I let a buddy of mine with no handgun experience shoot a few, and he did fine. Then he shot TWO full pressure rounds, and he didn't want any more.
Not sure of velocity. 4" groups at 50 yds were about as good as I could shoot. But that's about as good as I have been able to do with any 250-300 gr load.
I have a couple of hundred 300 gr Speer bullets, so I'll shoot a few of these with the Trail boss. 12.5 grains left about 1/8" or more under the seated bullet. That's about what I measured with 14.5 grains under the 250gr XTP give or take a little.
Come to think of it, a 300 gr bullet at 1000 fps (just guessing) will hammer down anything in my part of the world at 50 yds.