socal,
How's it going "homie"? ( I was born in Oceanside a long, long time ago!)
While I like Hodgdon powder I don't really care for Titegroup. I especially don't care for it in larger cases. For me, that includes the 45ACP. With the proper weights there just isn't enough in there to satisfy me. Very dense powder.
That being said, the Hodgdon data website calls for a minimum load of 4.2gr for a 180gr LRNFP and I would find it hard to believe that a reduction of .6gr in powder for 5gr of bullet weight is a good thing to do.
If it were me and I decided on Titegroup for a powder, I would use the minimum load for the 180gr LRNFP for a starting point.
I NEVER use less powder than the manufacturer recommends, I have used considerably more than their maximum at times though!