Can anyone give me a estimate of what point of impact change I can expect at 50 and 100 yards with a 4" 45 LC ( nomianl 800 ft/s ) load if sighted in at 25 yards?
It would all come down to bullet weight and actual velocity out of your gun. You need the Ballistic Chart for your load to get a good estimate, most of the major ammo manufactures websites have them for their loads.