I hunt with open sighted handguns and I'm acutely aware of the ideal combination of weight, sight radius, and portability. I've hunted for over 30 years with 8 3/8" 29s and 57s.
Last year I switched to a 500 S&W, and after much agonizing over barrel length choice, I selected a 6 1/2".
I find this revolver to be as comfortable as any 6" N frame when carried in a shoulder holster and though heavier than an N, the weight addition isn't noticeable for all day use.
IMHO, it is undoubtedly the best compromise between the 4" and the longer barreled 500s. Handle them all.... shoot them all.... and I believe you'll come to the same conclusion I have.
Good luck!!