I've had Hogues on my 625-8 45 ACP/AR for some time and they're good, but I recently put Pachmayr Presentations on my Model 19 and find them really comfortable, even though I have medium-sized hands, and the fit could be better. I've also got Altamont & Ahrends wood grips for the 625 and both look great but I think I prefer rubber, even though it doesn't look as classy.
Problem is- which Pachmayrs? They don't do a round-butt version of the Presentations for the N-frames. I don't mind finger grooves; aside from the Compacts all the Pachmayrs have grooves. I'd like a "full-size " grip as concealability isn't an issue. I've got it set up for 250 gr. HC bullets @ around 900 fps. so there's more recoil than .45 ACP loads, but it's not punishing. If the Grippers (which cover the backstrap?) are no bigger than the Presentations on my Model 19 they would be OK.