Can I put a vortex viper on my m&p full size 22lr?

If your 22 has an A3/A4 type upper, you should be able to.

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What do you mean A3 A4 upper?

I have a Vortex Strikefire on my "15-22", fits just fine, the rail should work just as well with a different scope.
I don't think I could get it on my M&P22 though!

BTW, the A3 A4 upper is the one with the full length rail, instead of a carry-handle rear sight. I don't know if you can get the 15-22 with one of those, though. Could be wrong.

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I think the OP is talking about the M&P FS 22LR if so there is a rail under the dust cover and you can get a mount that attaches to it so a optic can be used . I had mine rigger that way.

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M&P X5

I am talking about a full size 22lr m&p handgun