Given a proper holster, I don't see any reason why it would not. It's on the larger side - I've AIWBd a 4506 but that was too big when seated (for me - it's somewhat dependent on your body build and clothing fit - the rise of your pants) but I'm happier with 3.5" semiautos. I've AIWBd my Sigma (same size as your gun) with no trouble, and Gabe Suarez (a real AIWB evangelist) has lots of pix up of him with the same-sized Glock 19 in this carry mode.
Again - buy the right holster before you do this.
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