Normally I just shoot cheap FMJ ammo that isn't +P rated but since it's getting colder out am switching back to carrying my 4566TSW and have some Hornady Critical Duty +P 220G ammo that I plan on carrying with.
I don't suspect I'll encounter any issues but figured I'd ask before I put a box threw it and start carrying it like that.
Not even remotely an issue. These guns are tough.
So long as your recoil spring is healthy there'll be no problem.
Winchester RA45T +P is my chosen carry load