I have a 4566 with original grips and have been thinking about changing out to Hogue, if I decided to sell this gun would leaving the original grips on it make it more desirable?


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Simple enough answer: If/when you ever decide to sell the gun, offer the gun for sale with both sets of grips included.

Both.


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Always include the original grips in the sale.

I prefer the original, but having both gives the new user the option to try things out.