Yes, you will feel a difference for sure.
I have Hogue grips for almost all my 3rd Gens, and Colts. I am from the Pachmayr "Age". (Off went the beautiful, fully functional factory wood grips, on went the rubber.) Still can't remember where all that wonderful, and now valuable wood went.
None of my pistols have the Hogue's on now, but I will keep all of them. I have factory Delrin's on all the S&W's now, and those that had arched and flat profiles, I have both. I really like the arched, but will keep all the flat ones too. I actually do change them around.
The Hogue's are great for wet weather and/or sweaty hands, where as the factory ones can get slippery.
Jim