If you talk S&W into manufacturing .22 LR N frames I’ll buy one or two.
There were a few (literally only a few) factory 1st model N frame .22 LRs. A member posted that they were 8 shot but I haven’t seen reference to them not being 6 shot anywhere else.
There was also the .22 LR Registered Magnum. It was special ordered as a set of matching 8 3/8” revolvers, one in .357 and one in .22 LR. So far as I know it is a 6 shot. We have had threads speculating on it’s where abouts and what it might be worth.
A few British military .455 N frames were converted to .22 LR by sleeving their chambers and cylinders. Member gripper posted this thread on his .22 LR sleeved .455 Triple Lock a few months back:
Triple Lock sn# 2747 chambered in .22 Long Rifle