I haven't shot anything with a .380 except paper and reactive targets but I carry ball precisely because of concern about sufficient penetration in this caliber. I have chronographed a few ball rounds from the Keltec P3at. Surprisingly velocities are higher than one might expect from the stubby little barrel. I haven't laid hands on any Buffalo Bore-Arguably their hardcast flat point may be best in the .380 if it feeds well......I carry plain old Remington UMC. It chronos 900-1000+ fps out of my P3at...most rounds cross the chrony in the upper 900s. Independence(Federal) averages about 100fps slower.