In my opinion,you're overthinking this.You'll be using small batches of ammo for load development and that will be your main mission the first trip to the range.During the load testing,I'd recommend you sight in for 25 yards.(with the front sight of your preference).With a larger batch of ammo that you've settled on,fine tune the sights to hit where you want at 50 yards or whatever your choice is.Presumably,this will take place on your second trip to the range.