I still use 2400 for my standard 44 Mag loads...with240/250 grain bullets @ 1250...it always has been a performer. When I load the heavyweights (300 grains +), in my 44 Mags, at "top end" velocities, I find that 296 is my powder of choice, but, for midrange velocity loads with the heavyweights I have found again that 2400 does an excellent job. Like some have stated here..."the powder for the purpose". In all my 44 Mag loads be it midrange or top end (I do not shoot light loads), I also use Magnum Primers exclusively, but only because of the climate conditions I hunt under. I try to work up all my hunting loads at 30 to 35 degrees or so. This gives me a good temperature range for those loads to work within, and I have never had any inconsistancies with those loads from the mid 60's down to sub zero condtions.