Back in the Mesozoic Era, when I bought my first .45 Auto, I asked an old timer what powder to use for reloading the .45 ACP. He told me, "Use 5.0 Grains of Bullseye for any bullet, cast or jacketed, up to and including 230 grains." I don't always use 5.0 grains, but I've found he wasn't really wrong.