The increase of velocity of a projectile increases it's energy exponentially. That is a good point. Is that what you are trying to say? But don't forget ballistic co-efficients. A .22 Hornet is a poor caliber because it's not efficient for what it is. A 22LR is very efficient. Plus a 22 hornet is a 35 grain slug, a 10mm is a 180 grain slug on average. No, it's not even the same ball park in stopping power because a Hornet has to be shot from a very long barrel to obtain that energy. You are comparing rifles to pistols.