big bullets;
I have three S&W .44 Magnums. My deer hunter is a 8 3/8" and I also have a Ruger Red Hawk 7½". Both are scoped. Hodgdon's data is gathered with a closed breech pressure gun and the velocities, while correct for Hodgdon, do NOT reflect real world velocities.

I shoot all my own cast bullets. Your velocities are in line with mine in both the S&W and the Ruger.

I shoot a cast 250 gr Keith bullet. 23.0 grs of H110 give me 1200 fps and 24.0 grs give me 1300 fps. Both are about 100 fps less than I would have thought. However, the 1200 fps shot lenghtwise through a 200-250 lb buck hit at 75 yards. It was an instant kill (he was facing me and I broke his neck). The bullet was not recovered. Elmer Keith reported that 1200 fps was enough. I fully believe him.

I would not be afraid of going to 24.0 grs with your chosen bullet and you will probably get about 100 fps more. Whether that is important to you or not, it is there if you need/want it.

Good hunting!
Dale53