Originally Posted by mes227

460's energies are notably higher. The 460 puts a 360 gr (Bufallo Bore) bullet out at 1,900 fps while the 500 puts out a 400 gr bullet at 1,675. In terms of ME that's 2,860 versus 2,491 ft-lbs.
-- The 500 does have a slightly higher TKO (45 v. 50 at the muzzle for Buffalo Bore) but the difference is pretty minor and I think more than made up by the flatter trajectory and thus better bullet placement for any long-distance shot (and for anything close both rounds are more that sufficient for anything you're likely to shoot). And the 500 can deliver a 440 grain bullet while (as far as I can find) the largest factory ammo available for the 460 is 360 grain. Though I suspect that gap will close with time.

The one significant advantage of the 500, IMHO, is that a wider range of barrel lengths are available for new production. But there's a pretty good selection of barrels in used 460s. That said, I very much like the 500 in a shorter barrel just for the cool factor!