The biggest advantage to .25 ACP compared to .22LR is reliability, both feeding and ignition. If it were necessary for me to carry a .25, I would be feeding it Hornady 35 gr. JHP/XTP at 900fps which will expand. I'd also practice enough to insure that "minute of eye socket" was my normal accuracy level.
BTW, the only .25 I own is a Beretta 418, the model that James Bond carried before "M" made him switch to the PPK, ostensibly because the Beretta jammed too much.
Now
that was truly fiction - this pistol performs flawlessly.
Buck