It would be almost impossible to wear one out with factory equivalent loads like those made for the last 135 or so years.

That is, providing you don't cycle your cylinder fast when cocking SA or DA. That in itself will wear a gun loose much quicker than any sane load will. It wears the cylinder stop, stop window, and the stop notches much faster than a slower deliberate cycling of the action does, yet I see guys constantly thumbing back the hammer rather quickly.