I bought my 19-6 for home defense (nothing to jam/go wrong if things get strange). I find it easier to acquire a sight picture than most large automatics (especially since I "improved" the sights with neon green and red markings).

I also plan to carry it when hunting (again, it's simple so there's nothing to do but pull the trigger, and it's powerful enough with a .357 magnum hunting round to stop nearly anything that I might need to stop). And given the nasty things that can happen to a holstered gun during a hunt, I think the simplicity and reliability of a wheel gun makes sense.

YMMV, of course...