I have the 3" Pro-series in .45 and it is great. I will be using it today to demonstrate large muscle movement drills during a firearms class. I have held the .45 Sc "E" series and liked it so much that I ordered two that should be here any day. I prefer guns that are small enough to be carried concealed relatively easy. So, to answer your queston, I would pick the gun that fits your hand best, ie. hand width, finger length, finger strength, and pitch of your palm. Tie those criteria in with the intended purpose of the gun and you will be ready to choose. Hope this helps.