Sorry, no.

Every time you unscrew and screw a barrel back in it turns just a bit farther in each time due to compression of the barrel and frame shoulders.
Within just one or two times the front sight is going to be turned in to the left and will no longer be aligned at 12:00 O'clock top-dead-center.
Each time you do it, the front sight will end up farther and farther over.

Once you break the torque of a revolver barrel you can't just screw the barrel back in because it will no longer be a tight enough fit. The barrel will vibrate loose and unscrew itself. So, you have to screw it tighter, and this mis-aligns the front sight.
Once you break the torque of a revolver barrel, you have to totally re-fit the barrel by turning it in one more thread and completely re-fitting everything.

There have been non-Dan Wesson custom changeable barrel revolvers, but these all had some kind of barrel retention device that didn't depend on torquing the barrel in place.