Mini-guns, mouse guns, call them what you will ... as the size drops, the trade-off increases. The smaller the pistol, the less practical functionality it has. Personally speaking, I would never carry any type of pistol that resembles a prize out of a Cracker Jack box. The micro-guns I see touted in various periodicals and buyers guides may look cute, but I would not rely on one to keep me alive in a worst case scenario. If I were to carry a .22 for self-defense purposes, it would be a .22 J-Frame, and only a .22 J-Frame (something like a 317 Airlite). Any J-frame snub wearing boot grips can be concealed perfectly on the average person, be it ankle rig, IWB/OWB, pocket, etc. And if the J-frame is the choice, then there is no reason not to have .38s loaded, rather than .22s.