Yes, “canting” a barrel will cause shots to go in that direction. A good number of my revolvers (various brands) have barrels that don’t appear to be perfectly plumb to the frame, but they‘re on target with the rear sight close to center. The majority are canted left (viewed from the rear). If the rear sight had to be cranked all the way to regulate POI or if there wasn’t enough travel, I’d worry about it.

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