In Indiana the 45ACP cannot be used for deer hunting. The round has enough energy to do the work on small deer but I would think that the corn fed behemoths of our two states would be out of it's league any further out than 50 yards.

Of course, there are the hybrids out there too. 460 Rowland, 45 WinMag and either one of those would be more than adequate for any animal out to 100 yards. Just remember that there is going to be a considerable amount of drop to a 230gr bullet that started out at only 800fps @ that 100 yards. If you can get that weight bullet up to over 1000 fps, either by using one of the variants mentioned above OR shooting them in a revolver and running them over pressure or in +P and you my be good to go too.

For me, the 45ACP is my carry caliber. 2 legged @ less than 20 yards and they have had it! 4 legged though, give me a 45 Colt with Linebaugh's loads or a 44Mag in a carbine. Just sayin'