The 4506-1 slides will not work in the older 4506 frames. The 4506-1 frame dustcover has grooves on the top of it that match with the front of the slide to help reduce side by side play when cycling.
My 4506 has a rub mark on the slide (on the recoil spring tunnel) similar to what you see on a lot of 1911s. This design change to the frame and slide prevented that.
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Thanks,
KPSqured
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