Like said above, 4227 is more of a full power powder than a mid-range powder. It's also a forgotten powder too and I don't know why since it works very well in the .44 Magnum. BUT, there is load data for both IMR and H4227 in the new Lyman 4th Edition Cast Bullet Handbook using a 240gr cast bullet. If you want to use that powder just to give it a try here is the data:
They use a 4" universal receiver when developing this data.
240gr Lyman #429667 bullet, 1.645" OAL.
IMR4227, 21.5gr 1036 fps 29,000 CUP // 24.0gr 1263 fps 37,800 CUP
H4227, 20.7gr 1032 fps 27,500 CUP // 23.0gr 1248 fps 37,300 CUP
245gr Lyman #429421 bullet, 1.710" OAL.
IMR4227, 20.2gr 938 fps 21,300 CUP // 24.0gr 1196 fps 34,600 CUP
H4227, 21.5gr 1083 fps 29,400 CUP // 23.8gr 1281 fps 38,400 CUP
I gave you both listings because I don't know which bullet profile you have.
You can check the
Lyman site to compare your bullet to the bullets listed.
I hope that helps a bit...