I own two - a Model 24-3 Lew Horton, and a newer Model 21-4. They're both great guns. The N frame makes the .44 Special feel like a .38 Special. Like the .45ACP, they've had over 100 years to perfect the round. I think the succeeded beyond their vision!
PS - Yesterday, I saw a "Pre-Model 21", 5" barrel, box, tools, etc. What I wouldn't give to own that one. The owner was at $2,500 but he and the other guy were still dickering. It was a superb example of the genre.