Caution is a good practice when reloading anything but I do agree that extra care is a good idea with the .500.

On the other hand, the X frame is very stout and I doubt that anything other than a full case of Bullseye would take the gun apart.

The biggest concern would probably be detonation of low density loads with powders like W296/H110. If you use nearly casefulls of suitable powders that won't likely be an issue. Bottom end, use Trail Boss, I've had great results with it for dinky plinking loads.

You don't need to exceed published max load data to have extremely powerful rounds. Don