I like H110/W296 and use it in several calibers. I don't load 125gr bullets in the 357M because they can cause increased throat erosion. Back to the issue - the Python is know to cause higher than normal pressure due to tight barrels. This also contributes to their very fine accuracy. I believe Hornady used the Python because it would result in the most conservative loads. I don't know what kind of 10" barrel Hodgdon - probably a pressure barrel.

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Dick