Yep I carry mine with a round in chamber and safety off. I been carrying the BG380 for more than a year this way either in my pocket or in my IWB holster. The trigger pull is long and heavy so I don't worry about it. I have and do practice pulling gun so aware of trigger finger and with any gun, with or with out a safety you must know the gun. I do not know why they even have a safety on this gun but it is nice option if someone is dead set against no safety. I have put the safety on when it is not in my pocket or holster, other than that it is safety off.