Most of us don't have the ability to shoot 500+ rounds a week but I have heard of Model 64's with documented 70,000+ round counts before they needed to be rebuilt.

The French GIGN shoots every day and their .357 revolvers are a mainstay. I forget the exact amount but they shoot several hundred full bore .357's every day for training and the Ruger GP100 and Manurhin were the only revolvers they found were able to take the abuse of daily training.