I prefer the 645. I love the wood grip panels on mine, the high-polished slide and frame, the incredible accuracy and reliability. Don't get me wrong, I just picked up another 4506 and while I have yet to shoot it, it has a lousy, crunchy single action trigger pull, as opposed to a very smooth, light single action pull on the 645. Gotta go with the 645. JMHO.
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