I'd say find a theme,and concentrate on that (not that you'll likely be able to exclude acquiring other S&W's that pop up).

Some suggestions:

1) Pick a frame size - J or K would be typical choices.

2) Martials and/or law enforcment marked.

3) Nickeled.

4) Snubnosed.

5) An era - prewar, or postwar pre-model marked.

6) A particular caliber

Or whatever else strikes your fancy.

__________________
SWCA #590
"Colligo ergo sum"