A lot of good information here already. I agree W231 has it's limitations on magnum calibers, that's why I use 3 powders mostly. The original "Powder Trinity" before there were a lot of powders available was Bullseye, Unique and 2400. My powder trinity is W231 (HP-38), W540 (HS-6) and W296 (H110) I haven't found anything I can't load with those 3 powders or the other powder trinity either.
When I reach what I feel is the limit of W231 I go to HS-6. When I want full power magnum loads I turn to W296. Those 3 powder never fail me. Yes, I do have about 8 or more other handgun powder on the shelf but that's because I like to try new stuff. I always seem to come back to those 3. (Trail Boss, Clays, Universal, AA#5, Power Pistol, 2400, Lil'Gun, Longshot and maybe some I forgot)
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