A justified shooting is good shooting regardless of the type of ammo used. The only time the type of ammo may be brought into question is regarding your intent and that requires a lot of interpretation by jurors and prosecution. If you shoot an unknown to you ex fellon that breaks into your house and assaults you that's one thing. Shoot someone where a motive other than self defense could reasonably be inferred and the ammo type could be used against you.

If you plan on shooting +P+ LEO ammo make sure your gun will hold up to at least a limited amount of shooting such high pressure ammo. Personally I'd stick to using in revolvers chambered for the .357 mag. YOu are using this ammo at your own risk and voiding any warranty by doing so. If it shakes your gun loose out of time or stretches the frame you are going to be out the money to repair or replace the handgun on your own.