I recently picked up a new-to-me Colt Python and thought it would be cool to grab my Model 27-2 and try them out back to back at the range. The results were surprisingly close. In my examples, the Python is better finished and wins in the looks department, but in shooting they are both quite similar. Accuracy probably has to go to the Python as they lock up like no other revolver I have seen. Overall balance and recoil control is comparable, as are the sights. The trigger pulls are both fantastic, but in different ways. The Colt has an almost two stage pull in DA that I think will take some getting used to. The Python was made in '72 and the 27 was made in '76. They really did make some nice guns back then.

Here are a couple of pics (note that the original magnas on the 27 have been replaced temporarily with later target stocks)