Both calibers are great, but I have finally come to the conclusion that PENETRATION IS YOUR FRIEND! Exanguination is the VERY best bet to "stop the action." If you can "tear someone up" terribly and they bleed out, you're ahead of the game.

Several shots in the upper thoracic cavity will generally cause sufficient blood loss to cause the victim to become hypertensive (suffer from low blood pressure.) Death should follow reasonably soon. If one can puncture some vital organs, the onset of shock, and loss of blood pressure should ensue in between 15 and 180 seconds, depending on how many blood vessels have been ruptured.

Scott