I have a 325NG & really love it, though moon-clips can be a love/hate thing. I also have a 29-2 but I wouldn't consider it for prime home defense use unless necessity dictated it. You didn't indicate what size barrel you wanted? I think 4" or less is best for this use & a 2-1/2" or 3" will perform well at those distances, once you've practiced with it. It doesn't sound like you reload (I do) but if you did you'd have free range on power in either. If you're not going to do alot of target/range shooting, other than to get proficient with it, ammo price probably isn't a big deal & you can find a wide range available in each also. You can find reduced loads in 44Mag/Spcl. or hi-pwr 45 ACP/AR/Super loads. So factor in how much you want to shoot it, what you want to shoot it for, barrel length wanted, ammo demands & if anyone else in the house will use it, but it just might end up boiling down to what you can find available, especially lately.