Mith my neuropathy, I have weakness in my right hand and wrist. I have difficulty opening such things as a bag of chips or a Slim Jim so I just cut them open with a knife.
I needed a knife I could open and hold easily and ended up with a ten dollar Pawn Shop knife. It's assisted opening, has ambidextrous thumb studs, a flipper and a handle with a belt clip wide enough for my gimpy hand to hold onto.
I wouldn't use it for hunting but it does hold a decent edge and serves my needs well.
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