I own both an M+P 22 and a Ruger SR22 The two have a very different feel to them. One large, one on the compact side. Both shoot great, but the Ruger, in my opinion, is a better value dollar wise. You get 2 magazines, 2 floor plates, and 2 grips. They seem to run about the same price wise. Both are available with threaded barrel.
If I had to pick just one, it would be the Ruger. Fortunately I didnt have to choose.
Tom