Releasing the standard safety left handed isn't the problem I encountered. That's simply annoying.

The difficulty was in re-engaging the safety without having to go through some "contortions" to do it, with the potential for pointing the weapon in an undesirable direction before it has been made "safe".

As for the standard left-side safety interfering with the left-handed trigger finger, that's easily overcome by using an ambi-safety model that has a short and/or low-profile lever on that side, which I DID need to do.

What I still don't see a need for is a left-handed or ambidextrous charging handle...