I'm a big fan of 40SW, & have four pistols in that caliber. That being said, in my "vast" arsenal, if I were confronted by a large carnivore, I think I would have the most faith in my 686-2. A 40 might just tick the bear off. Or my 4516-1 or 4513TSW, hopefully loaded with some BA self defense loads. I know nothing about hunting, so please correct me if needed!