For use in a moderate load, & just having fun, there probably won't be much difference noticed. If you want, you could reload them all with the same load/powder, that's suitable for the heavier weight bullet, & then just put the light ones in one box & the heavies in another. Shoot one box first & then use up the others afterwards, so you won't have to be concerned with any differences they exhibit. (I'm assuming you still have them separated.)