I'd holster up the 21-4 loaded with 240 LSWC at about 1000-1100 FPS. There is nothing on two or four feet that that would not calm down permanently. I have a 21-4 that I positively adore! It is not nickle plated. I put a bit of white paint on the front sight It works extremely well at any normal distance one might figure on shooting such a revolver. It hammers steel targets hard. It will stay in the head of a man sized target at 25 yds. What more could anyone want?
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