Do you want DAO or traditional DA/SA? Metal frame or polymer? Are you looking more for a "pocket size" or larger? There are as many questions as answers. All we can do is make suggestions. There have been some really good suggestions so far.

Personally I prefer larger size autos. That's just me. I make no bones about the fact that the 4506 is my all time favorite. I find it to be extremely versatile. However, it may not be for you. The 4566 is another favorite of mine. For DAO I really enjoy my 4586. I have no experience with the 4516 but many knowledgeable folks here recommended them.

I also like my Glocks. I own several. I carry my 21 concealed as well as my 36. A very solid product and extremely reliable, which is what you want in a self defense gun.

You can't go wrong with any of the guns suggested. In my mind the only wrong choice would be with an M & P, but that's based on my personal experiences with them. I cannot under any circumstances recommended them.

__________________
Un-Reconstructed Southerner