Actually, it is the opposite. Larger cylinder means more steel for the rounds to hit. This is one reason why K-frames are considered the best choice for the sport (aside from the smaller and lighter cylinder also meaning a theoretically lighter trigger pull).

That being said...shoot what ya got (or what you love to shoot). Unless you are planning to try to win Master class, theory doesn't mean a whole lot.

If you do shoot a big match, be sure to check the weight of your gun. I was surprised to discover that my stock 686 with Pachmayrs on it was 1/10th of an ounce overweight (and thus illegal).