I run a 2wd shortbox F150 with all season mud/snow rated tires. If it snows, I slow down. If it snows too much (I am in MN and too much is relative) I stay home. Knowing how is as important as equipment, and avoiding trouble is a good start, and the biggest part of knowing how is knowing when to go slow.

My new Yokohamas' are doing well, in snow and on ice. I paid less for my first two cars together than for those 4 tires.