That is my EDC revolver of choice and the load I use for the mild recoil and quick follow up shots.
Of course my holster of choice is a Ransom rest....
It also helps with my arm wrestling training and carpel tunnel recovery regimen.

In all seriousness I had the pleasure of shooting a similar set up and found it no more disturbing than shooting 158 grain hard cast from my 340 Scandium. As the Corps stated to me many moons ago, " Pain is weakness leaving the body".
Happy Shooting